Article
A common variant at 8q24.21 is associated with renal cell cancer.
Nature communications - 1 Jan 2013
Gudmundsson Julius, Sulem Patrick, Gudbjartsson Daniel F, Masson Gisli, Petursdottir Vigdis, Hardarson Sverrir, Gudjonsson Sigurjon A, Johannsdottir Hrefna, Helgadottir Hafdis Th, Stacey Simon N, Magnusson Olafur Th, Helgason Hannes, Panadero Angeles, van der Zanden Loes F, Aben Katja K H, Vermeulen Sita H, Oosterwijk Egbert, Kong Augustine, Mayordomo Jose I, Sverrisdottir Asgerdur, Jonsson Eirikur, Gudbjartsson Tomas, Einarsson Gudmundur V, Kiemeney Lambertus A, Thorsteinsdottir Unnur, Rafnar Thorunn, Stefansson Kari
Abstract excerpt
Renal cell carcinoma (RCC) represents between 80 and 90% of kidney cancers. Previous genome-wide association studies of RCC have identified five variants conferring risk of the disease. Here we report the results from a discovery RCC genome-wide association study and replication analysis, including a total of 2,411 patients and 71,497 controls. One variant, rs35252396[CG] located at 8q24.21, is significantly...
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