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Article

Regulation of NGFI‐B/Nur77 gene expression in the rat ovary and in leydig tumor cells MA‐10

28 Dec 2007

Abstract excerpt

NR4A1, also called NGFI-B in the rat, Nur77 in the mouse and TR3 in humans, belongs to the orphan nuclear steroid hormone receptor superfamily and is one of the immediate-early genes. In the endocrine organs, including the gonads, NGFI-B/Nur77 gene expression is rapidly induced by pituitary hormones. NGFI-B/Nur77 expression was found to be rapidly reduced by an estrogenic endocrine disrupter, diethylstilbestrol...

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PMID: 18163434
DOI: 10.1002/mrd.20788

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