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Article

MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.

Molecular and cellular biology - 1 Jan 2007

Xia Yan, Wang Ji, Xu Shuichan, Johnson Gary L, Hunter Tony, Lu Zhimin

Abstract excerpt

c-Jun, a major transcription factor in the activating protein 1 family of regulatory proteins, is activated by many physiologic and pathological stimuli. We show here that c-Jun was downregulated in response to osmotic stress via ubiquitination-dependent degradation by the PHD/RING finger domain of MEKK1, which exhibited E3 ubiquitin ligase activity toward c-Jun in vitro and in vivo. The reduced c-Jun protein...

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Identifiers

PMID: 17101801
DOI: 10.1128/MCB.01355-06
PMCID: PMC1800814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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