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Article

Consequences of NMDA receptor deficiency can be rescued in the adult brain.

Molecular psychiatry - 1 Jul 2021

Mielnik Catharine A, Binko Mary A, Chen Yuxiao, Funk Adam J, Johansson Emily M, Intson Katheron, Sivananthan Nirun, Islam Rehnuma, Milenkovic Marija, Horsfall Wendy, Ross Ruth A, Groc Laurent, Salahpour Ali, McCullumsmith Robert E, Tripathy Shreejoy, Lambe Evelyn K, Ramsey Amy J

Abstract excerpt

N-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent connections in the developing and adult brain. Impaired NMDAR signalling through genetic or environmental insults causes a constellation of neurodevelopmental disorders that manifest as intellectual disability, epilepsy, autism, or schizophrenia. It is not clear whether the developmental impacts of NMDAR dysfunction can be overcome...

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Identifiers

PMID: 32807843
DOI: 10.1038/s41380-020-00859-4
PMCID: PMC8505246

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