Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What the genome sequence is revealing about trypanosome antigenic variation.

Biochemical Society transactions - 1 Nov 2005

Barry J D, Marcello L, Morrison L J, Read A F, Lythgoe K, Jones N, Carrington M, Blandin G, Böhme U, Caler E, Hertz-Fowler C, Renauld H, El-Sayed N, Berriman M

Abstract excerpt

African trypanosomes evade humoral immunity through antigenic variation, whereby they switch expression of the gene encoding their VSG (variant surface glycoprotein) coat. Switching proceeds by duplication of silent VSG genes into a transcriptionally active locus. The genome project has revealed that most of the silent archive consists of hundreds of subtelomeric VSG tandem arrays, and that most of these are not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Protozoan
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome

Source

Identifiers

PMID: 16246028
DOI: 10.1042/BST20050986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What the genome sequence is revealing about trypanosome antigenic variation.PMID 16246028Read ↗

Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation.Semantic proximity Read ↗

From silent genes to noisy populations-dialogue between the genotype and phenotypes of antigenic variation.Semantic proximity Read ↗

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity.Semantic proximity Read ↗

DNA Recombination Strategies During Antigenic Variation in the African Trypanosome.Semantic proximity Read ↗

Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosomeSemantic proximity Read ↗

Variant surface glycoprotein diversity in African trypanosomesSemantic proximity Read ↗

African trypanosomes: the genome and adaptations for immune evasionSemantic proximity Read ↗

Antigenic variation in A frican trypanosomes: the importance of chromosomal and nuclear context in VSG expression controlSemantic proximity Read ↗

The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolenseSemantic proximity Read ↗

Antigenic variation in trypansosomes: Secrets surface slowlySemantic proximity Read ↗

Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427.Semantic proximity Read ↗

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.