Article
Dimethylsulfoxide as modifier of the organospecific mutagenicity of metronidazole in mice.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1990
Hrelia P, Scotti M, Morotti M, Vigagni F, Paolini M, Sapigni E, Cantelli-Forti G
Abstract excerpt
Mutagenicity and carcinogenicity of metronidazole (MT) are imputable to the formation of toxic intermediates, which include radical forms derived from the nitroreductive process. Since dimethylsulfoxide (DMSO), the "universal" solvent, can quench free radicals in vitro, it was suggested that DMSO might protect by scavenging free radical generation in vivo. This study wanted to evaluate if DMSO (given...
Topics
- Animals
- Biotransformation
- Dimethyl Sulfoxide
- Kidney
- Liver
- Lung
- Male
- Metronidazole
- Mice
- Microsomes
- Microsomes, Liver
- Mutagenicity Tests