Article
Tissue-specific induction of mutations by streptozotocin in vivo.
Mutation research - 1 Jun 1994
Schmezer P, Eckert C, Liegibel U M
Abstract excerpt
Streptozotocin has been reported to induce DNA damage in mouse liver although malignant tumors were not induced in this organ. DNA damage had not yet been monitored in the mouse kidney which was the tumor target organ in two mouse studies. In order to elucidate target organ specificity of genotoxicity and of tumorigenesis, we investigated the induction of DNA damage (microgel electrophoresis assay) and mutations...
Topics
- Animals
- DNA Damage
- DNA Transposable Elements
- Electrophoresis
- Kidney
- Lac Operon
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutagenesis, Site-Directed