Article
Atrazine treatment potentiates excretion of mutagenic urine in 2,6-dinitrotoluene-treated Fischer 344 rats.
Environmental and molecular mutagenesis - 1 Jan 1995
George S E, Chadwick R W, Kohan M J, Allison J C, Warren S H, Williams R W
Abstract excerpt
Atrazine (ATZ), an s-triazine herbicide, is a widespread environmental contaminant. The hepatocarcinogenic component of technical grade dinitrotoluene, 2,6-dinitrotoluene (2,6-DNT, 19.5%), is a byproduct of trinitrotoluene synthesis and is found at production sites. This study explores the effect of ATZ treatment on the bioactivation of the promutagen, 2,6-DNT. Male Fischer 344 rats (5 weeks old) were...
Topics
- Animals
- Atrazine
- Biotransformation
- DNA Adducts
- Dimethyl Sulfoxide
- Dinitrobenzenes
- Drug Synergism
- Environmental Exposure
- Herbicides
- Intestines
- Male