Marked shortage of C4B DNA polymorphism among insulin-dependent diabetic patients.

doi:10.1016/0923-2494(90)90131-h

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Article

Marked shortage of C4B DNA polymorphism among insulin-dependent diabetic patients.

Research in immunology - 1 Feb 1990

Marcelli-Barge A, Poirier J C, Chantome R, Deschamps I, Hors J, Colombani J

Abstract excerpt

TaqI, BamHI and HinddIII polymorphisms of the C4 genes were studied with a 500-bp C4 cDNA probe (pAT-A153) specific for the 5' end of the gene. The restriction patterns obtained were correlated with the C4A and C4B genotypes in 35 patients suffering from insulin-dependent diabetes mellitus (IDDM)...

Topics

Alleles
Autoimmunity
Chromosomes, Human, Pair 6
Complement C4b
Diabetes Mellitus, Type 1
Disease Susceptibility
Female
Humans
Male
Pedigree
Polymorphism, Restriction Fragment Length

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