C4 polymorphism in multiplex families with insulin dependent diabetes in the Tunisian population: standard C4 typing methods and RFLP analysis.

doi:10.1016/0896-8411(92)90196-w

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Article

C4 polymorphism in multiplex families with insulin dependent diabetes in the Tunisian population: standard C4 typing methods and RFLP analysis.

Journal of autoimmunity - 1 Apr 1992

Jenhani F, Bardi R, Gorgi Y, Ayed K, Jeddi M

Abstract excerpt

The polymorphism of C4A and C4B genes was investigated in Tunisian patients with insulin dependent diabetes (IDDM) and compared to family members (sibs) and to healthy controls. Multiplex families were analysed. A significant increase in C4AQO (26.86% vs 6.90%) and C4BQO (40.29% vs 8.28%) phenotypes was noted in IDDM patients compared with controls. Using RFLP analysis, we confirmed the high frequency of C4 null...

Topics

Adolescent
Adult
Alleles
Autoimmune Diseases
Child
Child, Preschool
Complement C4a
Complement C4b
Diabetes Mellitus, Type 1
Female
HLA Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Major Histocompatibility Complex

Male

Phenotype

Polymorphism, Restriction Fragment Length

Tunisia

Source

Open in PubMed

Identifiers

PMID: 1352685
DOI: 10.1016/0896-8411(92)90196-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1352685-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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