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Article

Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons.

PloS one - 11 Sept 2009

Diaz-Ruiz Oscar, Zapata Agustin, Shan Lufei, Zhang YaJun, Tomac Andreas C, Malik Nasir, de la Cruz Fidel, Bäckman Cristina M

Abstract excerpt

The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for growth, proliferation and cell survival. Pten deletion in the mouse brain has revealed its role in controlling cell size and number. In this study, we used Cre-loxP...

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Share to Corpus Striatum
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Open in PubMed Open full text

Identifiers

PMID: 19750226
DOI: 10.1371/journal.pone.0007027
PMCID: PMC2736587

Genes

PTEN
DRD1
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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