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Article

The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals.

Neurobiology of disease - 1 Oct 2015

Stavarache Mihaela A, Musatov Sergei, McGill Marlon, Vernov Mary, Kaplitt Michael G

Abstract excerpt

Phosphatase and Tensin homolog deleted on chromosome 10 (PTEN) is a dual lipid-protein phosphatase known primarily as a growth preventing tumor suppressor. PTEN is also expressed in neurons, and pathways modulated by PTEN can influence neuronal function. Here we report a novel function of PTEN as a regulator of striatal dopamine signaling in a model of Parkinson's disease (PD). Blocking PTEN expression with an...

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Source

Identifiers

PMID: 26232589
DOI: 10.1016/j.nbd.2015.07.013

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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