Article
Functional evidence for D- and T-loop interactions in tmRNA.
FEBS letters - 6 Mar 2002
Barends Sharief, Björk Karl, Gultyaev Alexander P, de Smit Maarten H, Pleij Cornelis W A, Kraal Barend
Abstract excerpt
During bacterial protein synthesis, stalled ribosomes can be rescued by tmRNA, a molecule with both tRNA and mRNA features. The tRNA region of tmRNA has sequence similarity with tRNA(Ala) and also has a clover-leaf structure folded similarly as in canonical tRNAs. Here we propose the L-shape of tmRNA to be stabilized by two tertiary interactions between its D- and T-loop on the basis of phylogenetic and...
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