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Article

Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features.

Immunology and allergy clinics of North America - 1 Aug 2018

Lyons Jonathan J

Abstract excerpt

Hereditary alpha tryptasemia is an autosomal dominant genetic trait caused by increased germline copies of TPSAB1 encoding alpha-tryptase. Individuals with this trait have elevated basal serum tryptase, and may present with associated multisystem complaints. Both basal serum tryptase levels and severity of clinical symptoms display a gene-dose relationship with TPSAB1, whereby higher tryptase levels and greater...

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Topics

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Share to Connective Tissue
Share to Gene Duplication
Share to Hypersensitivity, Immediate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin E

Share to Mast Cells

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Source

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Identifiers

PMID: 30007465
DOI: 10.1016/j.iac.2018.04.003
PMCID: PMC6411063

Genes

TPSAB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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