Article
Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1.
The Journal of allergy and clinical immunology - 1 Feb 2021
Lyons Jonathan J, Chovanec Jack, O'Connell Michael P, Liu Yihui, Šelb Julij, Zanotti Roberta, Bai Yun, Kim Jiwon, Le Quang T, DiMaggio Tom, Schwartz Lawrence B, Komarow Hirsh D, Rijavec Matija, Carter Melody C, Milner Joshua D, Bonadonna Patrizia, Metcalfe Dean D, Korošec Peter
Abstract excerpt
BACKGROUND: An elevated basal serum tryptase level is associated with severe systemic anaphylaxis, most notably caused by Hymenoptera envenomation. Although clonal mast cell disease is the culprit in some individuals, it does not fully explain this clinical association. OBJECTIVE: Our aim was to determine the prevalence and associated impact of tryptase genotypes on anaphylaxis in humans. METHODS: Cohorts with...
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