Article

Genetically determining individualized clinical reference ranges for the biomarker tryptase can limit unnecessary procedures and unmask myeloid neoplasms

2022-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where baseline (BST) levels >20 ng/mL are a minor criterion for diagnosis. Whereas clonal myeloid neoplasms are rare, the common cause for elevated BST is the genetic trait hereditary alpha-tryptasemia (HαT) caused by increased germline TPSAB1 copy number. To date, the...

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Literature Corpus work: 9c4f42f3-36a8-5b94-8593-be423eec5a80
DOI: 10.1101/2022.04.29.22274379

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