Article
The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins.
The Journal of biological chemistry - 1 Aug 2008
Garcia-Dominguez Mario, March-Diaz Rosana, Reyes Jose C
Abstract excerpt
Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins regulates multiple processes in the eukaryotic cell. In numerous cases sumoylation is facilitated by protein inhibitor of activated STAT (PIAS) proteins, characterized by the presence of a SP-RING domain related to the RING finger of many ubiquitin E3 ligases. The importance of SP-RING relies on its capacity to bind the E2 enzyme of the...
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