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Article

SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.

The Biochemical journal - 16 Jul 2021

Gurzau Alexandra D, Horne Christopher R, Mok Yee-Foong, Iminitoff Megan, Willson Tracy A, Young Samuel N, Blewitt Marnie E, Murphy James M

Abstract excerpt

Structural maintenance of chromosomes flexible hinge domain-containing 1 (SMCHD1) is an epigenetic regulator that mediates gene expression silencing at targeted sites across the genome. Our current understanding of SMCHD1's molecular mechanism, and how substitutions within SMCHD1 lead to the diseases, facioscapulohumeral muscular dystrophy (FSHD) and Bosma arhinia microphthalmia syndrome (BAMS), are only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34109974
DOI: 10.1042/BCJ20210278
PMCID: PMC8286825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.PMID 34109974Read ↗

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SMCHD1 loss triggers DUX4 expression by disrupting splicing in FSHD2Semantic proximity Read ↗

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