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Article

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.

Nature - 12 Oct 2017

Prouteau Manoël, Desfosses Ambroise, Sieben Christian, Bourgoint Clélia, Lydia Mozaffari Nour, Demurtas Davide, Mitra Alok K, Guichard Paul, Manley Suliana, Loewith Robbie

Abstract excerpt

The target of rapamycin (TOR) is a eukaryotic serine/threonine protein kinase that functions in two distinct complexes, TORC1 and TORC2, to regulate growth and metabolism. GTPases, responding to signals generated by abiotic stressors, nutrients, and, in metazoans, growth factors, play an important but poorly understood role in TORC1 regulation. Here we report that, in budding yeast, glucose withdrawal (which...

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Identifiers

PMID: 28976958
DOI: 10.1038/nature24021
PMCID: PMC5640987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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