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Article

Detection of a novel mutation in exon 20 of the BRCA1 gene.

Cellular & molecular biology letters - 1 Dec 2013

Chakraborty Abhijit, Katarkar Atul, Chaudhuri Keya, Mukhopadhyay Ashis, Basak Jayasri

Abstract excerpt

Hereditary breast cancer constitutes 5-10% of all breast cancer cases. Inherited mutations in the BRCA1 and BRCA2 tumor-suppressor genes account for the majority of hereditary breast cancer cases. The BRCA1 C-terminal region (BRCT) has a functional duplicated globular domain, which helps with DNA damage repair and cell cycle checkpoint protein control. More than 100 distinct BRCA1 missense variants with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24297685
DOI: 10.2478/s11658-013-0110-3
PMCID: PMC6275959

Genes

BRCA1
BACH1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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