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Article

A new rapid methodological strategy to assess BRCA mutational status.

Molecular biotechnology - 1 Jul 2013

Vuttariello Emilia, Borra Marco, Calise Celeste, Mauriello Elvira, Greggi Stefano, Vecchione Aldo, Biffali Elio, Chiappetta Gennaro

Abstract excerpt

Hereditary cancers account for approximately 10 % of breast and ovarian cancers. Mutations of the BRCA1 and BRCA2 genes, encoding two proteins involved in DNA repair, underlie most cases of such hereditary cancers. Women with BRCA mutations develop breast cancer in 50-80 % of cases and ovarian cancer in 10-40 % of cases. Assessing BRCA mutational status is needed to direct the clinical management of women with...

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Source

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Identifiers

PMID: 23354980
DOI: 10.1007/s12033-012-9646-0
PMCID: PMC3641296

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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