Article
High-resolution melting analysis for rapid screening of BRCA1 and BRCA2 Spanish mutations.
Breast cancer research and treatment - 1 May 2009
de Juan Inmaculada, Esteban Eva, Palanca Sarai, Barragán Eva, Bolufer Pascual
Abstract excerpt
The majority of BRCA1 and BRCA2 mutation detection procedures include screening methods, all of which are time-consuming. High-resolution melting (HRM) is a promising pre-screening method of gene scanning that combines simplicity and rapid identification of genetic variants. We evaluated HRM in the screening of BRCA1/2 Spanish mutations. We studied 40 BRCA1 and 47 BRCA2 DNA samples with different Spanish...
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