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Article

Development of a High-Resolution Melting Approach for Scanning Beta Globin Gene Point Mutations in the Greek and Other Mediterranean Populations.

PloS one - 1 Jan 2016

Chassanidis Christos, Boutou Effrossyni, Voskaridou Ersi, Balassopoulou Angeliki

Abstract excerpt

Beta-thalassaemia is one of the most common autosomal recessive disorders worldwide. The disease's high incidence, which is observed in the broader Mediterranean area has led to the establishment of molecular diagnostics' assays to prevent affected births. Therefore, the development of a reliable, cost-effective and rapid scanning method for β globin gene point mutations, easily adapted to a routine laboratory,...

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PMID: 27351925
DOI: 10.1371/journal.pone.0157393
PMCID: PMC4924799

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