Article
Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells.
The Journal of biological chemistry - 23 Jan 2009
Li Hongbing, Ray Gibanananda, Yoo Byong Hoon, Erdogan Mete, Rosen Kirill V
Abstract excerpt
Resistance of solid tumor cells to anoikis, apoptosis induced by cell detachment from the extracellular matrix, is thought to be critical for the ability of these cells to grow anchorage independently within three-dimensional tumor masses and from metastases. Beta-catenin, a major oncoprotein, can inhibit anoikis of cancer cells via unknown mechanisms. In an effort to identify these mechanisms we found that...
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