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Article

Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses.

PloS one - 9 Sept 2009

Sakuma Toshie, Sakurai Akira, Yasuda Jiro

Abstract excerpt

Tetherin (also known as BST2, CD317 or HM1.24) has recently been reported to inhibit a wide range of viruses. However, the antiviral mechanism of action of tetherin has not been determined. Both ends of the tetherin molecule are associated with the plasma membrane and it forms a homodimer. Therefore, a model in which progeny virions are retained on the cell surface by dimer formation between tetherin molecules on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19742323
DOI: 10.1371/journal.pone.0006934
PMCID: PMC2735005

Genes

BST2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses.PMID 19742323Read ↗

Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and CounteractionSemantic proximity Read ↗

Inhibition of Lassa and Marburg Virus Production by TetherinSemantic proximity Read ↗

Tetherin and Its Viral AntagonistsSemantic proximity Read ↗

Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin ( BST-2 )Semantic proximity Read ↗

BST-2/tetherin: Structural biology, viral antagonism, and immunobiology of a potent host antiviral factorSemantic proximity Read ↗

Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling ActivitiesSemantic proximity Read ↗

Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by TetherinSemantic proximity Read ↗

Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivoSemantic proximity Read ↗

Feline Tetherin Is Characterized by a Short N-Terminal Region and Is Counteracted by the Feline Immunodeficiency Virus Envelope GlycoproteinSemantic proximity Read ↗

BST-2/tetherin: a new component of the innate immune response to enveloped virusesSemantic proximity Read ↗

Cloning and Characterization of the Antiviral Activity of Feline Tetherin/BST-2Semantic proximity Read ↗

Tetherin/BST-2: Restriction Factor or Immunomodulator?Semantic proximity Read ↗

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