Article
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
British journal of cancer - 20 Oct 2009
Cunningham J M, Vierkant R A, Sellers T A, Phelan C, Rider D N, Liebow M, Schildkraut J, Berchuck A, Couch F J, Wang X, Fridley B L, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther S A, Ramus S J, Pharaoh P D P, Goode E L
Abstract excerpt
BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide. METHODS: We examined single nucleotide polymorphisms (SNPs) (n=288) from 39 cell cycle regulation genes, including cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors, in a two-stage study. White, non-Hispanic cases (n=829) and ovarian cancer-free...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.