Article
Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.
Nature communications - 19 Aug 2014
Chen Kexin, Ma Hongxia, Li Lian, Zang Rongyu, Wang Cheng, Song Fengju, Shi Tingyan, Yu Dianke, Yang Ming, Xue Wenqiong, Dai Juncheng, Li Shuang, Zheng Hong, Wu Chen, Zhang Ying, Wu Xiaohua, Li Dake, Xue Fengxia, Li Haixin, Jiang Zhi, Liu Jibin, Liu Yuexin, Li Pei, Tan Wen, Han Jing, Jie Jiang, Hao Quan, Hu Zhibin, Lin Dongxin, Ma Ding, Jia Weihua, Shen Hongbing, Wei Qingyi
Abstract excerpt
Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P(meta)<10(-4)) in 960 EOC cases and...
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