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Rethinking ovarian cancer genomics: where genome-wide association studies stand?

Pharmacogenomics - 1 Nov 2017

Pinto Ricardo, Assis Joana, Nogueira Augusto, Pereira Carina, Pereira Deolinda, Medeiros Rui

Abstract excerpt

Genome-wide association studies (GWAS) allow the finding of genetic variants associated with several traits. Regarding ovarian cancer (OC), 15 GWAS have been conducted since 2009, with the discovery of 49 SNPs associated with disease susceptibility and 46 with impact in the clinical outcome of patients (p < 5.00 × 10-2). Among them, 14 variants reached the genome-wide significance (p < 5.00 × 10-8). Despite the...

Topics

Alleles
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomics
Genotype
Humans
Ovarian Neoplasms
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29095100
DOI: 10.2217/pgs-2017-0108

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