Article
Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed.
The Journal of biological chemistry - 13 Nov 2009
Pletnev Sergei, Gurskaya Nadya G, Pletneva Nadya V, Lukyanov Konstantin A, Chudakov Dmitri M, Martynov Vladimir I, Popov Vladimir O, Kovalchuk Mikhail V, Wlodawer Alexander, Dauter Zbigniew, Pletnev Vladimir
Abstract excerpt
KillerRed is the only known fluorescent protein that demonstrates notable phototoxicity, exceeding that of the other green and red fluorescent proteins by at least 1,000-fold. KillerRed could serve as an instrument to inactivate target proteins or to kill cell populations in photodynamic therapy. However, the nature of KillerRed phototoxicity has remained unclear, impeding the development of more phototoxic...
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