Article
Crystal Structure of Phototoxic Orange Fluorescent Proteins with a Tryptophan-Based Chromophore.
PloS one - 1 Jan 2015
Pletneva Nadya V, Pletnev Vladimir Z, Sarkisyan Karen S, Gorbachev Dmitry A, Egorov Evgeny S, Mishin Alexander S, Lukyanov Konstantin A, Dauter Zbigniew, Pletnev Sergei
Abstract excerpt
Phototoxic fluorescent proteins represent a sparse group of genetically encoded photosensitizers that could be used for precise light-induced inactivation of target proteins, DNA damage, and cell killing. Only two such GFP-based fluorescent proteins (FPs), KillerRed and its monomeric variant SuperNova, were described up to date. Here, we present a crystallographic study of their two orange successors, dimeric...
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