Article
CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults.
Annals of the New York Academy of Sciences - 1 Apr 2002
Cosentino Anna, Gambelunghe Giovanni, Tortoioli Cristina, Falorni Alberto
Abstract excerpt
Latent autoimmune diabetes in adults (LADA) is identified by the presence of GAD65 autoantibodies in diabetic patients who do not require insulin treatment for at least six months after the diagnosis. Previous studies have shown that the risk for LADA, similarly to type 1 diabetes mellitus (T1DM), is increased in subjects carrying the HLA-DRB1*03-DQA1*0501-DQB1*0201 and/or HLA-DRB1*04-DQA1*0301-DQB1*0302...
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