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Article

The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis.

Acta diabetologica - 1 Oct 2014

Dong Fang, Yang Guang, Pan Hong-Wei, Huang Wei-Huang, Jing Li-Peng, Liang Wen-Kai, Zhang Na, Zhang Bao-Huan, Wang Man, Liu Yang, Zhang Li-Ju, Zhang Si-Heng, Li He, Chen Chuan, Nie Li-Hong, Jing Chun-Xia

Abstract excerpt

Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes and LADA. We performed a systematic review by identifying relevant studies and applied...

Read the complete abstract on PubMed

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Share to CTLA-4 Antigen
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PTPN22 gene

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Open in PubMed Open full text

Identifiers

PMID: 25005490
DOI: 10.1007/s00592-014-0613-z
PMCID: PMC4176954

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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