Article
A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.
The Journal of clinical investigation - 1 Oct 2009
Mandinova Anna, Kolev Vihren, Neel Victor, Hu Bing, Stonely Wesley, Lieb Jocelyn, Wu Xunwei, Colli Claudia, Han Rong, Pazin Michael J, Pazin Mike, Ostano Paola, Dummer Reinhard, Brissette Janice L, Dotto G Paolo
Abstract excerpt
Seborrheic keratoses (SKs) are common, benign epithelial tumors of the skin that do not, or very rarely, progress into malignancy, for reasons that are not understood. We investigated this by gene expression profiling of human SKs and cutaneous squamous cell carcinomas (SCCs) and found that several genes previously connected with keratinocyte tumor development were similarly modulated in SKs and SCCs, whereas the...
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