Article
Low incidence of oncogenic EGFR, HRAS, and KRAS mutations in seborrheic keratosis.
The American Journal of dermatopathology - 1 Aug 2014
Georgieva Ivelina A, Mauerer Andreas, Groesser Leopold, Herschberger Eva, Aslanidis Charalampos, Dietmaier Wolfgang, Landthaler Michael, Hafner Christian
Abstract excerpt
Seborrheic keratosis (SK) represents a frequent epidermal skin tumor. Although lacking a malignant potential, these tumors reveal multiple oncogenic mutations. A previous study identified activating mutations in 89% of SK, particularly in FGFR3 and PIK3CA genes. The aim of this study was to identify further oncogenic mutations in human SK. Therefore, we screened for mutations in EGFR, FGFR2, PIK3R1, HRAS, KRAS,...
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