Article
Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors.
Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2010
Hafner Christian, Toll Agustí, Fernández-Casado Alejandro, Earl Julie, Marqués Miriam, Acquadro Francesco, Méndez-Pertuz Marinela, Urioste Miguel, Malats Núria, Burns Julie E, Knowles Margaret A, Cigudosa Juan C, Hartmann Arndt, Vogt Thomas, Landthaler Michael, Pujol Ramón M, Real Francisco X
Abstract excerpt
Malignant tumors result from the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Much less is known about the genetic changes in benign tumors. Seborrheic keratoses (SK) are very frequent benign human epidermal tumors without malignant potential. We performed a comprehensive mutational screen of genes in the FGFR3-RAS-MAPK and phosphoinositide 3-kinase (PI3K)-AKT pathways from 175 SK,...
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