Article
FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2007
Hafner Christian, Hartmann Arndt, van Oers Johanna M M, Stoehr Robert, Zwarthoff Ellen C, Hofstaedter Ferdinand, Landthaler Michael, Vogt Thomas
Abstract excerpt
Somatic activating fibroblast growth factor 3 (FGFR3) mutations in human skin can cause seborrheic keratoses, one of the most frequent skin tumors in man. However, details of the involved mechanisms remain elusive. We analyzed 65 acanthotic seborrheic keratoses with varying vertical diameters for FGFR3 mutations using a SNaPshot multiplex assay. Immunohistochemistry was performed for Ki-67, bcl-2 and FGFR3...
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