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Article

The Conundrum of Genetic "Drivers" in Benign Conditions.

Journal of the National Cancer Institute - 1 Aug 2016

Kato Shumei, Lippman Scott M, Flaherty Keith T, Kurzrock Razelle

Abstract excerpt

Advances in deep genomic sequencing have identified a spectrum of cancer-specific passenger and driver aberrations. Clones with driver anomalies are believed to be positively selected during carcinogenesis. Accumulating evidence, however, shows that genomic alterations, such as those inBRAF,RAS,EGFR,HER2,FGFR3,PIK3CA,TP53,CDKN2A, andNF1/2, all of which are considered hallmark drivers of specific cancers, can also...

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PMID: 27059373
DOI: 10.1093/jnci/djw036
PMCID: PMC5017937

Genes

EGFR
FGFR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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