Article
Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Nov 2012
Toncheva Antoaneta A, Suttner Kathrin, Michel Sven, Klopp Norman, Illig Thomas, Balschun Tobias, Vogelberg Christian, von Berg Andrea, Bufe Albrecht, Heinzmann Andrea, Laub Otto, Rietschel Ernst, Simma Burkhard, Frischer Thomas, Genuneit Jon, von Mutius Erika, Kabesch Michael
Abstract excerpt
BACKGROUND: Recently, Protocadherin-1 (PCDH1) was reported as a novel susceptibility gene for bronchial hyper-responsiveness (BHR) and asthma. PCDH1 is located on chromosome 5q31-33, in the vicinity of several known candidate genes for asthma and allergy. To exclude that the associations observed for PCDH1 originate from the nearby cytokine cluster, an extensive linkage disequilibrium (LD) analysis was performed....
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