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Article

Escherichia coli cells resistant to the DNA gyrase inhibitor, ciprofloxacin, overproduce a 60 kD protein homologous to GroEL.

Molecular microbiology - 1 Mar 1990

Hallett P, Mehlert A, Maxwell A

Abstract excerpt

Using a variety of mutagenic methods, we have generated a series of ciprofloxacin-resistant mutants derived from Escherichia coli strains which overproduce the DNA gyrase A protein. Many of these mutants are found to overexpress a 60 kD protein which is shown to be highly homologous in terms of N...

Topics

Amino Acid Sequence
Anti-Infective Agents
Bacterial Proteins
Chaperonin 60
Ciprofloxacin
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Escherichia coli
Heat-Shock Proteins
Microbial Sensitivity Tests
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Weight

Mutation

Topoisomerase II Inhibitors

Source

Identifiers

PMID: 1972534
DOI: 10.1111/j.1365-2958.1990.tb00602.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1972534-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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