Article
Sequence analysis and phenotypic characterization of groEL mutations that block lambda and T4 bacteriophage growth.
Journal of bacteriology - 1 Feb 1993
Zeilstra-Ryalls J, Fayet O, Baird L, Georgopoulos C
Abstract excerpt
The groES and groEL genes of Escherichia coli have been shown previously to belong to a single operon under heat shock regulation. Both proteins have been universally conserved in nature, as judged by the presence of similar proteins throughout evolution. The GroEL protein has been shown to bind promiscuously to many unfolded proteins, thus preventing their aggregation. ATP hydrolysis by GroEL results in the...
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