Error-prone DNA polymerase IV is regulated by the heat shock chaperone GroE in Escherichia coli.

Abstract excerpt

An insertion in the promoter of the operon that encodes the molecular chaperone GroE was isolated as an antimutator for stationary-phase or adaptive mutation. The groE operon consists of two genes, groES and groEL; point mutations in either gene conferred the same phenotype, reducing Lac+ adaptive mutation 10- to 20-fold. groE mutant strains had 1/10 the amount of error-prone DNA polymerase IV (Pol IV). In recG+...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptation, Biological
• Share to Chaperonin 10
• Share to Chaperonin 60