Article
Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer.
Breast cancer research and treatment - 1 Nov 2012
Neumeister Veronique M, Sullivan Catherine A, Lindner Robert, Lezon-Geyda Kimberley, Li Jia, Zavada Jan, Martel Maritza, Glazer Peter M, Tuck David P, Rimm David L, Harris Lyndsay
Abstract excerpt
The purpose of this study is to explore the relationship between tumor hypoxia assessed by CA IX protein expression and loss of BRCA1 function in triple negative breast cancer (TNBC). Protein expression of CA IX and BRCA1 was evaluated by AQUA™ technology on two breast cancer cohorts: an unselected cohort of 637 breast cancer patients and a TNBC cohort of 120 patients. Transcriptional profiling was performed on...
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