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Article

MDM4 (MDMX) and its Transcript Variants

1 Mar 2009

Abstract excerpt

MDM family proteins are crucial regulators of the oncosuppressor p53. Alterations of their gene status, mainly amplification events, have been frequently observed in human tumors.MDM4 is one of the two members of the MDM family. The human gene is located on chromosome 1 at q32-33 and codes for a protein of 490aa. In analogy to MDM2, besides the full-length mRNA several transcript variants of MDM4 have been...

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PMID: 19721810
DOI: 10.2174/138920209787581280

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