Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and expression of a novel MDM4 splice variant in human glioma.

Brain research - 6 Nov 2013

Wang Xiaowen, Sheng Ping, Guo Xingzhong, Wang Junyu, Hou Lijun, Hu Guohan, Luo Chun, Dong Yan, Lu Yicheng

Abstract excerpt

The product of the MDMX (or MDM4) gene is structurally related to the MDM2 oncoprotein and is also capable of interacting with the tumor suppressor protein p53. The MDM4 gene is overexpressed in several human tumors, while its product can be detected as various isoforms. This study was aimed to find the presence of aberrant mRNA transcripts of MDM4 in human glioma and their association with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Cell Cycle Proteins
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Protein Isoforms

Share to Proto-Oncogene Proteins

Share to RNA Splicing

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 23994448
DOI: 10.1016/j.brainres.2013.07.054

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and expression of a novel MDM4 splice variant in human glioma.PMID 23994448Read ↗

MDM4 (MDMX) and its Transcript VariantsSemantic proximity Read ↗

Alternative and aberrant splicing of MDM2 mRNA in human cancer.Semantic proximity Read ↗

Short alternative splice transcripts of the mdm2 oncogene correlate to malignancy in human astrocytic neoplasms.Semantic proximity Read ↗

Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.Semantic proximity Read ↗

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis.Semantic proximity Read ↗

An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and TumorigenesisSemantic proximity Read ↗

CD24 Expression as a Marker for Predicting Clinical Outcome in Human GliomasSemantic proximity Read ↗

Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cellsSemantic proximity Read ↗

The role of a single nucleotide polymorphism of MDM2 in glioblastoma multiforme.Semantic proximity Read ↗

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.Semantic proximity Read ↗

Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer.Semantic proximity Read ↗

Novel mdm2 splice variants identified in pediatric rhabdomyosarcoma tumors and cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.