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Article

Mdm2: Open questions.

Cancer science - 1 Jul 2020

Dobbelstein Matthias, Levine Arnold J

Abstract excerpt

The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a cornucopia of activities and regulatory pathways have been associated with it. In this review, we will raise questions about Mdm2 and its cousin Mdm4 that we consider worth pursuing in future research, reaching from molecular structures and intracellular activities all the way to development, evolution, and cancer therapy. We...

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Identifiers

PMID: 32335977
DOI: 10.1111/cas.14433
PMCID: PMC7385351

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