Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells.

doi:10.1080/09553009014551211

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Article

Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells.

International journal of radiation biology - 1 Jun 1990

Whaley J M, Kassis A I, Kinsey B M, Adelstein S J, Little J B

Abstract excerpt

Survival and the induction of mutations at the hprt and tk loci were measured in TK6 human lymphoblastoid cells following treatment with the DNA-intercalating agent 125iodoacetylproflavine (125IAP). 125IAP was readily taken up into the cells, was localized to the nucleus, and was released rapidly...

Topics

Acridines
Cell Line
Cell Nucleus
Cell Survival
Humans
Hypoxanthine Phosphoribosyltransferase
In Vitro Techniques
Intercalating Agents
Iodine Radioisotopes
Mutation
Proflavine
Thymidine Kinase

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