Article
Induction of mutations by bismuth-212 alpha particles at two genetic loci in human B-lymphoblasts.
Radiation research - 1 Dec 1992
Metting N F, Palayoor S T, Macklis R M, Atcher R W, Liber H L, Little J B
Abstract excerpt
The human lymphoblast cell line TK6 was exposed to the alpha-particle-emitting radon daughter 212Bi by adding DTPA-chelated 212Bi directly to the cell suspension. Cytotoxicity and mutagenicity at two genetic loci were measured, and the molecular nature of mutant clones was studied by Southern blot analysis. Induced mutant fractions were 2.5 x 10(-5)/Gy at the hprt locus and 3.75 x 10(-5)/Gy at the tk locus....
Topics
- Alpha Particles
- B-Lymphocytes
- Bismuth
- Humans
- Mutation
- Radioisotopes