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Article

Induction of mutations in TK6 human lymphoblastoid cells by ethyl methanesulphonate, benzo[a]pyrene and benzidine.

Mutagenesis - 1 Jan 1990

O'Brien K A, Gatehouse D G, Tiley M

Abstract excerpt

The experiments described were carried out as part of the UKEMS Third Collaborative Trial. The method used was essentially that described by Thilly et al., based on a cloning assay using microtitre test plates. The induction of mutations at both the thymidine kinase (tk) locus and the hypoxanthin...

Topics

Animals
Benzidines
Benzo(a)pyrene
Biotransformation
Cell Line
Cell Survival
Ethyl Methanesulfonate
Humans
Hypoxanthine Phosphoribosyltransferase
Microsomes, Liver
Multicenter Studies as Topic
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Mutation

Rats

Thymidine Kinase

Source

Identifiers

PMID: 2184322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2184322-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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