Article
The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains.
Molecular and cellular biology - 1 Jan 2005
Jin Yong Hwan, Garg Parie, Stith Carrie M W, Al-Refai Hanan, Sterling Joan F, Murray Laura J W, Kunkel Thomas A, Resnick Michael A, Burgers Peter M, Gordenin Dmitry A
Abstract excerpt
Until recently, the only biological function attributed to the 3'-->5' exonuclease activity of DNA polymerases was proofreading of replication errors. Based on genetic and biochemical analysis of the 3'-->5' exonuclease of yeast DNA polymerase delta (Pol delta) we have discerned additional biological roles for this exonuclease in Okazaki fragment maturation and mismatch repair. We asked whether Pol delta...
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