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Article

Mutational analysis of Pyrococcus furiosus replication factor C based on the three-dimensional structure.

Extremophiles : life under extreme conditions - 1 Jun 2003

Ishino Sonoko, Oyama Takuji, Yuasa Mihoko, Morikawa Kosuke, Ishino Yoshizumi

Abstract excerpt

In eukaryotic DNA replication, replication factor C (RFC) acts as a "clamp loader" that loads PCNA onto a primed DNA template in an ATP-dependent manner. Proteins with functions essentially identical to that of RFC exist in Archaea. We have determined the crystal structure of the small subunit (RFCS) of Pyrococcus furiosus RFC at 2.8-A resolution. Using the information from the determined tertiary structure, we...

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PMID: 12768447
DOI: 10.1007/s00792-002-0308-1

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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